The reasons for the discontinuation included sesame oil vehicle allergy, hepatotoxicity, excessive sleepiness and poor efficacy, gastrointestinal intolerance, worsening of seizures and hyperammonaemia CBD Gummies. In addition, 25 (15%) patients included in the safety analysis were not included in the efficacy analysis. The most frequent epileptic syndromes treated were Dravet Syndrome and Lennox-Gastaut Syndrome.
Titration was performed up to a maximum dose of 50 mg / kg / day in 48 (30%) patients, 23 of whom received a dose of more than 25 mg / kg / day during the 12 weeks of the observation period; only 19 patients were receiving> 25 mg / kg / day in the week 12 consultation.
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